Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstr. 41, 1st Floor, 6020, Innsbruck, Austria.
Department of Pneumology, District Hospital Vöcklabruck, Vöcklabruck, Austria.
Mycopathologia. 2018 Feb;183(1):161-170. doi: 10.1007/s11046-017-0175-z. Epub 2017 Jul 12.
N-Chlorotaurine (NCT) is a mild long-lived oxidant that can be applied to sensitive body regions as an endogenous antiseptic. Enhancement of its microbicidal activity in the presence of proteinaceous material because of transchlorination, a postantibiotic/postantifungal effect and antitoxic activity renders it interesting for treatment of fungal infections, too. This is confirmed by first case applications in skin and mucous membranes of different body sites. Recent findings of good tolerability of inhaled NCT suggest further investigations of this substance for treatment of bronchopulmonary diseases, where microorganisms play a role, particularly multi-resistant ones. The availability of a well-tolerated and effective inhaled antiseptic with anti-inflammatory properties could be a significant progress, in particular for chronic pulmonary diseases, such as chronic obstructive pulmonary disease or cystic fibrosis.
N-氯代牛磺酸（NCT）是一种温和的长寿命氧化剂，可作为内源性防腐剂应用于敏感的身体部位。由于转氯作用，即在抗生素/抗真菌治疗后，其在蛋白质物质存在的情况下增强杀菌活性，以及抗毒活性，使其对真菌感染的治疗也具有意义。这一点已通过在不同身体部位的皮肤和粘膜的首例应用案例得到证实。最近发现吸入 NCT 的良好耐受性，提示进一步研究这种物质在支气管肺部疾病中的应用，这些疾病中微生物发挥作用，特别是多耐药微生物。具有良好耐受性和有效的、具有抗炎特性的吸入性防腐剂的出现，可能是一个重大进展，特别是对于慢性肺部疾病，如慢性阻塞性肺疾病或囊性纤维化。
