Partap R, Kaur I, Chakrabarti A, Kumar B
Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Dermatology. 2004;208(1):55-9. doi: 10.1159/000075047.
The new antifungal triazoles itraconazole and fluconazole have revolutionized the treatment of pityriasis versicolor. Both drugs have shown promising results in different dose schedules.
To compare the efficacy and safety of single oral dose treatment with fluconazole versus itraconazole in patients with pityriasis versicolor.
A total of 40 patients with pityriasis versicolor were allocated randomly to group A and group B. A single dose of fluconazole (400 mg) or itraconazole (400 mg) was given orally to group A or group B patients, respectively. Patients were assessed mycologically by KOH and culture. Culture was done from lesional and perilesional skin to quantify growth and to observe the effect of these drugs and the persistence/reappearance of the fungus in relation to relapse at 2 and 8 weeks. Relapse was defined as reappearance or worsening of clinical signs and symptoms or positive KOH/culture after initial improvement.
Thirteen (65%) patients in the fluconazole group and 4 (20%) patients in the itraconazole group became culture negative at the end of 8 weeks. Relapse was found to be higher in the itraconazole group compared to the fluconazole group (60 vs. 35%). A direct correlation was found between the relapse rate and positivity of perilesional skin for Malassezia furfur.
In the same dosing, fluconazole was found to be more effective than itraconazole; however, both drugs were found to be safe.
新型抗真菌三唑类药物伊曲康唑和氟康唑彻底改变了花斑癣的治疗方法。两种药物在不同剂量方案下均显示出了有前景的结果。
比较氟康唑与伊曲康唑单剂量口服治疗花斑癣患者的疗效和安全性。
总共40例花斑癣患者被随机分配到A组和B组。A组和B组患者分别口服单剂量氟康唑（400mg）或伊曲康唑（400mg）。通过氢氧化钾（KOH）和培养进行真菌学评估。从皮损和皮损周围皮肤进行培养，以量化生长情况，并观察这些药物的效果以及真菌在2周和8周时与复发相关的持续存在/再次出现情况。复发定义为初始改善后临床体征和症状再次出现或加重，或KOH/培养结果呈阳性。
8周结束时，氟康唑组13例（65%）患者培养结果转为阴性，伊曲康唑组4例（20%）患者培养结果转为阴性。发现伊曲康唑组的复发率高于氟康唑组（60%对35%）。发现复发率与糠秕马拉色菌皮损周围皮肤阳性率之间存在直接相关性。
在相同给药剂量下，发现氟康唑比伊曲康唑更有效；然而，两种药物均被发现是安全的。
