[鼻息肉治疗后的肾上腺功能不全]
[Adrenal insufficiency after treatment of nasal polyposis].
作者信息
Bonfils P, Norès J-M, Malinvaud D, Bozec H, Avan P
机构信息
Service ORL et Chirurgie Cervico-Faciale, Hôpital Européen Georges Pompidou, Faculté Necker Enfants Malades, Université René Descartes, 20 rue Leblanc, F-75015 Paris, France.
出版信息
Ann Otolaryngol Chir Cervicofac. 2003 Dec;120(6):338-42.
OBJECTIVE
Assessment of hypothalamic-pituitary-adrenal (HPA) axis after long term and uncontrolled corticosteroid treatment in nasal polyposis.
PATIENTS AND METHODS
A short synacthen test was performed in ten patients who received uncontrolled doses of corticosteroids in a population of 128 patients treated for nasal polyposis.
RESULTS
Mean yearly dose of oral prednisone administered in short-term treatment varied between 1280 and 7300 mg. Mean daily dose of inhaled beclomethasone varied between zéro and 2000 microg. Morning plasmatic cortisol was abnormal in seven the patients before and after the stimulation (respectively 140 nmole/l and 359 nmole/l).
DISCUSSION
High and uncontrolled doses of corticosteroids in nasal polyposis affect HPA axis.
目的
评估长期无节制使用皮质类固醇治疗鼻息肉后下丘脑 - 垂体 - 肾上腺（HPA）轴的情况。
患者与方法
在128例接受鼻息肉治疗的患者中，对10例接受无节制剂量皮质类固醇治疗的患者进行了短效促肾上腺皮质激素试验。
结果
短期治疗中口服泼尼松的年均剂量在1280至7300毫克之间。吸入倍氯米松的日均剂量在0至2000微克之间。刺激前后，7例患者早晨血浆皮质醇异常（分别为140纳摩尔/升和359纳摩尔/升）。
讨论
鼻息肉患者高剂量且无节制使用皮质类固醇会影响HPA轴。
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