Pahlavani M A
Geriatric Research, Education, and Clinical Center (GRECC - 182) Audie L. Murphy Memorial Veterans Hospital, 7400 Merton Minter Boulevard, San Antonio, TX 78284, USA.
J Nutr Health Aging. 2004;8(1):38-47.
Nutrition has been shown to have a significant impact on aging. Caloric Restriction (CR), i.e., undernutrition not malnutrition, significantly increases the survival of laboratory animals by retarding/delaying the aging process. CR has beneficial effects on various physiological systems, including the immune system. Overall, the immunological status of rodents fed a restricted diet is superior to the immunological status of the non-restricted animals. It is believed that CR might retard aging and immunosenescence through a mechanism involving changes in signal transduction and gene expression. Recent studies from our laboratory support the view that the mechanism of CR involves changes in the activation of the upstream signaling molecules and cytokine gene expression that are altered with age.
营养已被证明对衰老有重大影响。热量限制（CR），即营养不良而非营养不足，通过延缓衰老过程显著提高实验动物的存活率。CR对包括免疫系统在内的各种生理系统都有有益影响。总体而言，食用限制饮食的啮齿动物的免疫状态优于未限制饮食的动物。据信，CR可能通过涉及信号转导和基因表达变化的机制延缓衰老和免疫衰老。我们实验室最近的研究支持这样一种观点，即CR的机制涉及上游信号分子激活的变化以及随年龄改变的细胞因子基因表达。
