Estrada-Camarena Erika, Fernández-Guasti Alonso, López-Rubalcava Carolina
Depto de Farmacobiología CINVESTAV-IPN, Calzada de los Tenorios 235, Col Granjas Coapa, Deleg Tlalpan, CP 14330 México DF, México.
Psychopharmacology (Berl). 2004 Apr;173(1-2):139-45. doi: 10.1007/s00213-003-1707-4. Epub 2004 Jan 17.
Several reports suggest that estrogens possess antidepressant effects and could facilitate the action of some antidepressants.
To analyze the interaction between three different types of estrogens, 17 beta-estradiol (E(2)), ethinylestradiol (EE(2)) or diethyl-stilbestrol (DES) and the antidepressants, fluoxetine (FLX) or desipramine (DMI) in ovariectomized female rats subjected to an animal model for the study of antidepressant compounds, the forced swimming test (FST).
The effect of the combination of a sub-optimal dose of FLX (2.5 mg/kg) or DMI (2.5 mg/kg) with a sub-active dose of E(2 )(10 microg/kg), EE(2), (2.5 or 5 microg/kg) or DES (1 mg/kg) was analyzed in both the FST and the open field paradigm.
The combination of a sub-optimal dose of E(2) or DES with that of the antidepressant DMI resulted in a clear antidepressant-like effect, evidenced by a significant decrease in immobility accompanied by an increase in climbing behavior. Sub-optimal doses of either E(2) or DES also facilitated the antidepressant-like effect of a sub-optimal dose of FLX. In this case, a decrease in immobility with a concomitant increase in swimming behavior was observed. Finally, the combination of EE(2) with either DMI or FLX decreased immobility and induced an increase in both swimming and climbing behaviors. All combinations decreased rats' locomotor activity when evaluated in the open field test.
In the FST estrogens were able to facilitate the action of two different kinds of antidepressants; however, these effects were dependent on the type of estrogen used.
多项报告表明，雌激素具有抗抑郁作用，并且可能会促进某些抗抑郁药的疗效。
在用于研究抗抑郁化合物的动物模型——强迫游泳试验（FST）中，分析三种不同类型的雌激素，即17β-雌二醇（E₂）、炔雌醇（EE₂）或己烯雌酚（DES）与抗抑郁药氟西汀（FLX）或地昔帕明（DMI）之间的相互作用。
在FST和旷场范式中，分析亚最佳剂量的FLX（2.5mg/kg）或DMI（2.5mg/kg）与亚活性剂量的E₂（10μg/kg）、EE₂（2.5或5μg/kg）或DES（1mg/kg）联合使用的效果。
亚最佳剂量的E₂或DES与抗抑郁药DMI联合使用产生了明显的抗抑郁样效应，表现为不动时间显著减少，同时攀爬行为增加。亚最佳剂量的E₂或DES也促进了亚最佳剂量FLX的抗抑郁样效应。在这种情况下，观察到不动时间减少，同时游泳行为增加。最后，EE₂与DMI或FLX联合使用均减少了不动时间，并诱导游泳和攀爬行为增加。在旷场试验中评估时，所有联合用药均降低了大鼠的运动活性。
在FST中，雌激素能够促进两种不同抗抑郁药的作用；然而，这些效应取决于所使用的雌激素类型。
