Suppiej A, Montini G, Casara G, Polo A, Zacchello G, Zacchello F
Department of Pediatrics, University of Padova, Italy.
Child Nephrol Urol. 1992;12(4):197-201.
Subclinical involvement of the nervous system in uremic adults has been detected by modern neurophysiological techniques. Chronic anemia is one of the possible factors responsible for neural dysfunction in uremia. We evaluated neurophysiological (brainstem auditory and somatosensory evoked potential) abnormalities and their possible modification following anemia correction with recombinant human erythropoietin in 14 children with end-stage renal disease maintained by hemodialysis. Only peripheral and 8th cranial nerve electrophysiological data are significantly abnormal in our patients, and they are not acutely modified by anemia correction. These data confirm the importance of electrophysiological testing of uremic children for detecting nervous system involvement at an early stage and for monitoring the efficacy of its management.
现代神经生理学技术已检测出尿毒症成年患者存在神经系统的亚临床受累情况。慢性贫血是导致尿毒症神经功能障碍的可能因素之一。我们评估了14例接受血液透析维持治疗的终末期肾病患儿的神经生理学（脑干听觉和体感诱发电位）异常情况，以及使用重组人促红细胞生成素纠正贫血后这些异常情况可能发生的变化。在我们的患者中，仅外周和第8对脑神经的电生理数据显著异常，且贫血纠正后这些数据并未发生急性改变。这些数据证实了对尿毒症患儿进行电生理检测对于早期发现神经系统受累情况以及监测其治疗效果的重要性。
