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接受隔日泼尼松治疗的肾小球病男孩青春期生长突增延迟

Delayed pubertal growth spurt in glomerulopathic boys receiving alternate-day prednisone.

作者信息

Polito C, Di Toro R

机构信息

Department of Pediatrics, 1st Faculty of Medicine and Surgery, University of Naples, Italy.

出版信息

Child Nephrol Urol. 1992;12(4):202-7.

PMID:1473093
Abstract

Statural growth was studied in 16 glomerulopathic children, 12 boys and 4 girls, treated with alternate-day prednisone for more than 2 years. Five patients were older than 12 years when started on therapy. Growth velocity was significantly slower in boys who received therapy during peripubertal age than in younger boys taking similar amounts of prednisone. In boys, pubertal growth spurt was delayed and shorter than normal, but growth continued with a velocity greater than normal for some years and kept on after 19 years of age. The ultimate height of the patients followed up after 19 years of age ranged within the normal limits of genetic height potential.

摘要

对16名肾小球病患儿(12名男孩和4名女孩)进行了身高增长研究,这些患儿接受隔日泼尼松治疗超过2年。5名患者开始治疗时年龄超过12岁。青春期前后接受治疗的男孩的生长速度明显慢于服用相似剂量泼尼松的年幼儿童。在男孩中,青春期生长突增延迟且比正常情况短,但生长在数年内以高于正常的速度持续进行,并在19岁后仍继续。19岁后随访的患者的最终身高在遗传身高潜力的正常范围内。

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