Singh Rajendra P, Shreeve Jean'ne M
Department of Chemistry, University of Idaho, Moscow, Idaho 83844-2343, USA.
Acc Chem Res. 2004 Jan;37(1):31-44. doi: 10.1021/ar030043v.
Synthetic and structural aspects of organofluorine compounds continue to be the focal points of vigorous research activities, as evidenced by the appearance of a large number of publications. Among the various useful methodologies for the introduction of fluorine into organic molecules, electrophilic fluorination is a promising and exciting area of research. While a variety of electrophilic fluorinating reagents are available, currently 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (Selectfluor) provides a remarkably straightforward and effective route. The breadth of applications realizable from this reagent in its role as a key electrophilic fluorinating reagent is highlighted here. This Account covers the literature for electrophilic fluorination reactions that employ Selectfluor during the period January 1999-January 2003.
有机氟化合物的合成及结构方面仍然是大量研究活动的焦点，大量出版物的出现证明了这一点。在将氟引入有机分子的各种有用方法中，亲电氟化是一个有前景且令人兴奋的研究领域。虽然有多种亲电氟化试剂可用，但目前1-氯甲基-4-氟-1,4-二氮杂双环[2.2.2]辛烷双（四氟硼酸）盐（Selectfluor）提供了一条非常直接有效的途径。本文突出了该试剂作为关键亲电氟化试剂时可实现的应用广度。本综述涵盖了1999年1月至2003年1月期间使用Selectfluor进行亲电氟化反应的文献。
