关于注意力缺陷多动障碍的基因研究的政策与伦理意义。
The policy and ethical implications of genetic research on attention deficit hyperactivity disorder.
作者信息
Yeh Max, Morley Katherine I, Hall Wayne D
机构信息
Office of Public Policy and Ethics, Institute for Molecular Bioscience, The University of Queensland, St Lucia Queensland, 4072, Australia.
出版信息
Aust N Z J Psychiatry. 2004 Jan-Feb;38(1-2):10-9. doi: 10.1111/j.1440-1614.2004.01292.x.
OBJECTIVE
To review the policy and ethical implications of recent research on the molecular genetics of attention deficit hyperactivity disorder (ADHD).
METHOD
MEDLINE and psycINFO database searches were used to identify studies on the genetics of ADHD. The implications of replicated candidate genes are discussed.
RESULTS
The findings for most genes have been inconsistent but several studies have implicated the genes in the dopaminergic pathway in the aetiology of ADHD.
CONCLUSIONS
The current evidence on the genetics of ADHD is insufficient to justify genetic screening tests but it will provide important clues as to the aetiology of ADHD. Genetic information on susceptibility to ADHD has the potential to be abused and to stigmatize individuals. Researchers and clinicians need to be mindful of these issues in interpreting and disseminating the results of genetic studies of ADHD.
目的
回顾近期注意力缺陷多动障碍（ADHD）分子遗传学研究的政策及伦理意义。
方法
通过检索MEDLINE和psycINFO数据库来识别关于ADHD遗传学的研究。讨论了已复制的候选基因的意义。
结果
大多数基因的研究结果并不一致，但有几项研究表明多巴胺能途径中的基因与ADHD的病因有关。
结论
目前关于ADHD遗传学的证据不足以证明基因筛查测试的合理性，但它将为ADHD的病因提供重要线索。关于ADHD易感性的基因信息有可能被滥用并给个体带来污名。研究人员和临床医生在解释和传播ADHD基因研究结果时需要留意这些问题。
Zotero 插件