Mayer B J, Baltimore D
The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
Trends Cell Biol. 1993 Jan;3(1):8-13. doi: 10.1016/0962-8924(93)90194-6.
In 1986, Pawson's group recognized a region of homology between two oncogenic tyrosine kinases that lay outside the catalytic domain. They termed this the Src homology 2, or SH2, domain. In the ensuing years, SH2 domains have been found in an impressive variety of proteins, as has a second region of homology, inevitably termed SH3. These domains appear to mediate controlled protein-protein interactions. Many proteins that contain SH2 and SH3 domains are involved in signal transduction, suggesting a new paradigm for regulation of intracellular signalling pathways.
1986年，鲍森的研究小组在两个致癌酪氨酸激酶的催化结构域之外发现了一个同源区域。他们将其命名为Src同源2结构域，即SH2结构域。在随后的几年里，人们发现SH2结构域存在于各种各样令人印象深刻的蛋白质中，同时还发现了另一个同源区域，不可避免地被命名为SH3结构域。这些结构域似乎介导了可控的蛋白质-蛋白质相互作用。许多含有SH2和SH3结构域的蛋白质都参与信号转导，这为细胞内信号通路的调控提出了一种新的模式。
