重组与RNA加工：存在共同脉络？

Recombination and RNA processing: a common strand?

作者信息

Kearsey S, Kipling D

机构信息

Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.

出版信息

Trends Cell Biol. 1991 Nov;1(5):110-2. doi: 10.1016/0962-8924(91)90101-e.

DOI:10.1016/0962-8924(91)90101-e

PMID:14731541

Abstract

Genetic recombination is a basic cellular process required for altering genome structure. The RecA protein of Escherichia coli has a central role in homologous recombination, and a eukaryotic protein with similar properties has been discovered in the yeast Saccharomyces cerevisiae. Unexpectedly, this RecA-like protein has additional biochemical activities, and its function may not be restricted to recombination.

摘要

基因重组是改变基因组结构所需的基本细胞过程。大肠杆菌的RecA蛋白在同源重组中起核心作用，并且在酿酒酵母中发现了具有类似性质的真核蛋白。出乎意料的是，这种类RecA蛋白具有额外的生化活性，其功能可能不限于重组。