控制核因子κB、Rel和背侧蛋白核摄取的蛋白质。

Proteins controlling the nuclear uptake of NF-kappa B, Rel and dorsal.

作者信息

Schmitz M L, Henkel T, Baeuerle P A

机构信息

Laboratorium für Molekulare Biologie der Ludwig-Maximilians-Universität, Genzentrum, Am Klopferspitz, D-8033 Martinsried, FRG.

出版信息

Trends Cell Biol. 1991 Nov;1(5):130-7. doi: 10.1016/0962-8924(91)90118-s.

DOI:10.1016/0962-8924(91)90118-s

PMID:14731544

Abstract

The two DNA-binding subunits of the transcription factor NF-kappa B, the products of the rel oncogene family and the product of the developmental control gene dorsal of Drosophila are homologous within a 300 amino acid region. This sequence represents a novel DNA-binding and dimerization domain. The access of the NF-kappa B/Rel/dorsal (NRD) transcription factor family to the cell nucleus is regulated. There is now evidence that functionally and structurally related accessory proteins of NF-kappa B, Rel and dorsal control the nuclear entry as well as DNA-binding activity of the transcription factors. This review summarizes current knowledge about the nuclear-uptake regulatory proteins (NURPs) I kappa B-alpha, I kappa B-beta/pp40 and cactus.

摘要

转录因子NF-κB的两个DNA结合亚基、rel癌基因家族的产物以及果蝇发育控制基因dorsal的产物在300个氨基酸区域内具有同源性。该序列代表一个新的DNA结合和二聚化结构域。NF-κB/Rel/dorsal（NRD）转录因子家族进入细胞核的过程受到调控。现在有证据表明，与NF-κB、Rel和dorsal在功能和结构上相关的辅助蛋白控制着转录因子的核内进入以及DNA结合活性。本综述总结了目前关于核摄取调节蛋白（NURPs）IκB-α、IκB-β/pp40和cactus的知识。