Fakan S
Centre of Electron Microscopy, University of Lausanne, 27 Bugnon, 1005 Lausanne, Switzerland.
Trends Cell Biol. 1994 Mar;4(3):86-90. doi: 10.1016/0962-8924(94)90180-5.
Ultrastructural investigation of the cell nucleus has so far been the only high-resolution approach for in situ analysis of its structural components and their roles in nuclear functions. Such studies have shown that perichromatin fibrils are the in situ form of hnRNA transcripts. Current evidence strongly supports the idea that they are also sites of pre-mRNA processing steps such as splicing and polyadenylation.
迄今为止，细胞核的超微结构研究一直是对其结构成分及其在核功能中的作用进行原位分析的唯一高分辨率方法。此类研究表明，染色质周缘纤维是hnRNA转录本的原位形式。目前的证据有力地支持了这样一种观点，即它们也是前体mRNA加工步骤（如剪接和聚腺苷酸化）的发生位点。
