Martin S J
Department of Immunology, University College London Medical School, Arthur Stanley House, 40-50 Tottenham Street, London, UK W1P 9PG.
Trends Cell Biol. 1993 May;3(5):141-4. doi: 10.1016/0962-8924(93)90128-n.
Apoptosis, a controlled form of cell death, appears to be regulated in several ways. Early studies indicated that de novo protein synthesis was required for apoptosis of thymocytes, but more recent studies have found that other cells can undergo apoptosis when protein synthesis is blocked or that inhibition of protein or RNA synthesis can induce apoptosis. Whether these findings reflect distinct forms of apoptosis or variations on a single pathway is not yet known. In this article the case for a single pathway to apoptosis, accessible at multiple points, is discussed.
细胞凋亡是一种受控制的细胞死亡形式，其似乎通过多种方式进行调节。早期研究表明，胸腺细胞凋亡需要从头合成蛋白质，但最近的研究发现，当蛋白质合成受阻时，其他细胞也能发生凋亡，或者抑制蛋白质或RNA合成可诱导细胞凋亡。这些发现反映的是细胞凋亡的不同形式还是单一途径的变体，目前尚不清楚。本文讨论了存在一条可在多个点进入的细胞凋亡单一途径的情况。
