钙离子对白细胞运动的调节。

Regulation of leukocyte locomotion by Ca2+.

作者信息

Maxfield F R

机构信息

Department of Pathology, Columbia University, 630 West 168th Street, New York, NY 10032, USA.

出版信息

Trends Cell Biol. 1993 Nov;3(11):386-91. doi: 10.1016/0962-8924(93)90088-i.

DOI:10.1016/0962-8924(93)90088-i

PMID:14731656

Abstract

Neutrophils migrate towards sites of inflammation and infection by chemotaxis. Their motility is dependent on the actin cytoskeleton and on adhesion to extracellular substrates, but how these are regulated in response to stimuli is not clear. This review focuses on the potential role of Ca(2+) as a second messenger in neutrophil motility. Several effects of Ca(2+) and Ca(2+)-binding proteins on the stability and crosslinking of actin polymers have been demonstrated in vitro. Nevertheless, the complex mechanism by which Ca(2+) regulates actin in neutrophils is not fully understood. In addition, intracellular Ca(2+) regulates the intergin-mediated adhesion of neutrophils to extracellular matrix.

摘要

中性粒细胞通过趋化作用向炎症和感染部位迁移。它们的运动性依赖于肌动蛋白细胞骨架以及与细胞外基质的黏附，但这些在受到刺激时是如何被调节的尚不清楚。本综述聚焦于Ca(2+)作为中性粒细胞运动中的第二信使的潜在作用。在体外已证实Ca(2+)和Ca(2+)结合蛋白对肌动蛋白聚合物的稳定性和交联有多种作用。然而，Ca(2+)调节中性粒细胞中肌动蛋白的复杂机制尚未完全明确。此外，细胞内Ca(2+)调节中性粒细胞通过整合素介导与细胞外基质的黏附。