钙库操纵性钙内流介质STIM和Orai的形式与功能
Forms and functions of store-operated calcium entry mediators, STIM and Orai.
作者信息
Putney James W
机构信息
National Institute of Environmental Health Sciences - NIH, Research Triangle Park, NC 27709, USA.
出版信息
Adv Biol Regul. 2018 May;68:88-96. doi: 10.1016/j.jbior.2017.11.006. Epub 2017 Nov 22.
Abstract
Calcium signals arise by multiple mechanisms, including mechanisms of release of intracellular stored Ca, and the influx of Ca through channels in the plasma membrane. One mechanism that links these two sources of Ca is store-operated Ca entry, the most commonly encountered version of which involves the extensively studied calcium-release-activated Ca (CRAC) channel. The minimal and essential molecular components of the CRAC channel are the STIM proteins that function as Ca sensors in the endoplasmic reticulum, and the Orai proteins that comprise the pore forming subunits of the CRAC channel. CRAC channels are known to play significant roles in a wide variety of physiological functions. This review discusses the multiple forms of STIM and Orai proteins encountered in mammalian cells, and discusses some specific examples of how these proteins modulate or mediate important physiological processes.
摘要
钙信号通过多种机制产生，包括细胞内储存钙的释放机制以及钙通过质膜通道的内流。连接这两种钙来源的一种机制是储存-操作性钙内流，其中最常见的形式涉及广泛研究的钙释放激活钙（CRAC）通道。CRAC通道的最小和必需分子成分是在内质网中作为钙传感器发挥作用的STIM蛋白，以及构成CRAC通道孔形成亚基的Orai蛋白。已知CRAC通道在多种生理功能中发挥重要作用。本综述讨论了在哺乳动物细胞中遇到的STIM和Orai蛋白的多种形式，并讨论了这些蛋白如何调节或介导重要生理过程的一些具体例子。
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本文引用的文献
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Adv Biol Regul. 2018 Jan;67:148-162. doi: 10.1016/j.jbior.2017.10.012. Epub 2017 Oct 27.
2
ORAI2 modulates store-operated calcium entry and T cell-mediated immunity.ORAI2 调节钙库操纵性钙内流和 T 细胞介导的免疫。
Nat Commun. 2017 Mar 15;8:14714. doi: 10.1038/ncomms14714.
3
Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain.胚胎小鼠大脑皮质神经元天然储存式钙通道的药理学特性
Front Pharmacol. 2016 Dec 12;7:486. doi: 10.3389/fphar.2016.00486. eCollection 2016.
4
The functions of store-operated calcium channels.储存操纵钙通道的功能。
Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):900-906. doi: 10.1016/j.bbamcr.2016.11.028. Epub 2016 Nov 30.
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Male infertility in mice lacking the store-operated Ca(2+) channel Orai1.缺乏储存式钙离子通道Orai1的小鼠的雄性不育
Cell Calcium. 2016 Apr;59(4):189-97. doi: 10.1016/j.ceca.2016.02.007. Epub 2016 Feb 27.
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