凋亡核酸内切酶：细胞死亡后进行清理？

The apoptosis endonucleases: cleaning up after cell death?

作者信息

Peitsch M C, Mannherz H G, Tschopp J

机构信息

Institute of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland.

出版信息

Trends Cell Biol. 1994 Feb;4(2):37-41. doi: 10.1016/0962-8924(94)90002-7.

DOI:10.1016/0962-8924(94)90002-7

PMID:14731864

Abstract

The term apoptosis describes the predictable structural changes associated with many forms of programmed cell death. One of the first visible events of apoptosis is the collapse of the nucleus. Nuclear degradation is manifested by digestion of chromatin into nucleosome-sized fragments or multiples of these. This digestion of DNA is enzymatic, and several attempts have been made to characterize apoptosis-specific endodeoxyribonucleases. Although there are strong candidates for such enzymes, direct evidence for their role in apoptosis is yet to be provided.

摘要

凋亡这一术语描述了与多种形式的程序性细胞死亡相关的可预测的结构变化。凋亡最早可见的事件之一是细胞核的崩解。核降解表现为染色质被消化成核小体大小的片段或其倍数。DNA的这种消化是酶促反应，人们已经进行了几次尝试来鉴定凋亡特异性的内切脱氧核糖核酸酶。尽管有强有力的候选酶，但它们在凋亡中作用的直接证据尚未得到。