染色质组织再审视。
Chromatin organization re-viewed.
作者信息
Woodcock C L, Horowitz R A
机构信息
Dept of Biology and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA 01003, USA.
出版信息
Trends Cell Biol. 1995 Jul;5(7):272-7. doi: 10.1016/s0962-8924(00)89038-8.
The predominant view of chromatin structure is that the beaded chain of nucleosomes is folded into a symmetrical helical fibre. Recently, however, direct evidence from cryoelectron microscopy and other imaging techniques confirms a non-symmetrical organization, consistent with modelling based on the heterogeneity of linker DNA lengths. This mode of chromatin folding is more compatible with the range of functional states in the living nucleus.
关于染色质结构的主流观点是，核小体的串珠链折叠成对称的螺旋纤维。然而，最近来自冷冻电子显微镜和其他成像技术的直接证据证实了一种非对称结构，这与基于连接DNA长度异质性的模型一致。这种染色质折叠模式与活细胞核中的一系列功能状态更相符。
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