Brady S T
Dept of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75235-9111, USA.
Trends Cell Biol. 1995 Apr;5(4):159-64. doi: 10.1016/s0962-8924(00)88980-1.
Over the past decade, a remarkable number and diversity of molecular motors have been described in eukaryotic cells. In addition to the identification of novel forms of myosin and dynein, the kinesins have been defined as an entirely new family of molecular motors. There may be as many as 30 different genes in a single organism encoding members of the kinesin superfamily. Why is such diversity in molecular motors needed? The biochemical and functional diversity of the originally defined form of kinesin provides some insights into the roles of molecular motors in cellular dynamics.
在过去十年中,真核细胞中已描述了数量众多、种类多样的分子马达。除了鉴定出肌球蛋白和动力蛋白的新形式外,驱动蛋白已被定义为一个全新的分子马达家族。单个生物体中可能有多达30个不同的基因编码驱动蛋白超家族的成员。为什么需要分子马达有如此的多样性呢?最初定义的驱动蛋白形式的生化和功能多样性为分子马达在细胞动力学中的作用提供了一些见解。