Andrews N W
Dept of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
Trends Cell Biol. 1995 Mar;5(3):133-7. doi: 10.1016/s0962-8924(00)88965-5.
The protozoan parasite Trypanosoma cruzi uses an unusual mechanism to enter cells. Recent observations revealed that instead of trypanosomes being brought in to fuse with lysosomes, it is the lysosomes that migrate to the trypanosomes and actually participate in their internalization. Signalling events involving intracellular free Ca2+ occur upon contact of the parasites with host cells and may contribute to the regulation of this unusual process.
原生动物寄生虫克氏锥虫利用一种不同寻常的机制进入细胞。最近的观察结果表明，不是锥虫被带入细胞与溶酶体融合，而是溶酶体迁移到锥虫处并实际参与它们的内化过程。寄生虫与宿主细胞接触时会发生涉及细胞内游离钙离子的信号事件，这可能有助于调节这一不同寻常的过程。
