Department of Pediatrics, Northwestern University, Chicago, IL 60611, USA.
Exp Parasitol. 2010 Nov;126(3):283-91. doi: 10.1016/j.exppara.2010.06.023. Epub 2010 Jun 18.
The protozoan parasite Trypanosoma cruzi, the etiologic agent of Chagas disease, is an obligate intracellular protozoan pathogen. Overlapping mechanisms ensure successful infection, yet the relationship between these cellular events and clinical disease remains obscure. This review explores the process of cell invasion from the perspective of cell surface interactions, intracellular signaling, modulation of the host cytoskeleton and endosomal compartment, and the intracellular innate immune response to infection.
原生动物寄生虫克氏锥虫，恰加斯病的病原体，是一种必需的细胞内原生动物病原体。重叠的机制确保了成功的感染，但这些细胞事件与临床疾病之间的关系仍然不清楚。这篇综述从细胞表面相互作用、细胞内信号转导、宿主细胞骨架和内体区室的调节以及感染的细胞内先天免疫反应的角度探讨了细胞入侵的过程。
