Desai S B, Moonim M T, Gill A K, Punia R S, Naresh K N, Chinoy R F
Department of Pathology, Tata Memorial Hospital, Mumbai-400 012, India.
Breast. 2000 Oct;9(5):267-70; discussion 270. doi: 10.1054/brst.2000.0134.
The objectives of this study were to document the oestrogen and progesterone receptor (ER & PR) status of breast cancer in the Indian population (as done by immunohistochemistry on paraffin blocks), and correlate the steroid receptor status of breast cancer with all relevant patient and tumour characteristics. Our current data have been compared with previously published data from other centres. In contrast to the higher rates reported in the Western literature, only 32.6% of our tumours were ER positive and 46.1% were PR positive. Tumours were separated into four categories: ER+PR+ (25%), ER+PR- (7.4%), ER-PR+ (21.1%) and ER-PR- (46.5%). ER and PR immunoreactivity increased with advancing age, and correlated with the presence of elastosis. Infiltrating lobular carcinoma, mucinous carcinoma, and mixed tumours were more frequently ER & PR positive. High-grade infiltrating duct carcinomas, pure comedo ductal carcinoma in situ, and medullary carcinoma were predominantly ER & PR negative. The presence of necrosis and lymphovascular invasion showed an inverse relationship with ER and PR reactivity.
本研究的目的是记录印度人群乳腺癌的雌激素和孕激素受体（ER & PR）状态（通过对石蜡块进行免疫组织化学检测），并将乳腺癌的类固醇受体状态与所有相关的患者和肿瘤特征进行关联。我们目前的数据已与其他中心先前发表的数据进行了比较。与西方文献报道的较高比例相比，我们的肿瘤中只有32.6%为ER阳性，46.1%为PR阳性。肿瘤被分为四类：ER+PR+（25%）、ER+PR-（7.4%）、ER-PR+（21.1%）和ER-PR-（46.5%）。ER和PR免疫反应性随年龄增长而增加，并与弹性组织变性的存在相关。浸润性小叶癌、黏液癌和混合性肿瘤的ER和PR阳性更为常见。高级别浸润性导管癌、单纯粉刺型导管原位癌和髓样癌主要为ER和PR阴性。坏死和淋巴管浸润的存在与ER和PR反应性呈负相关。
