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精神分裂症额叶功能障碍的近红外光谱分析

Near-infrared spectroscopy analysis of frontal lobe dysfunction in schizophrenia.

作者信息

Shinba Toshikazu, Nagano Mitsuru, Kariya Nobutoshi, Ogawa Kazuo, Shinozaki Takiko, Shimosato Seiji, Hoshi Yoko

机构信息

Department of Stress Disorders Research and Integrative Neuroscience, Tokyo Institute of Psychiatry, Tokyo, Japan.

出版信息

Biol Psychiatry. 2004 Jan 15;55(2):154-64. doi: 10.1016/s0006-3223(03)00547-x.

Abstract

BACKGROUND

Previous studies have shown that near-infrared spectroscopy (NIRS) has high temporal resolution, requires little restraint, and is suitable for examining the effect of psychological tasks on brain circulation. In the present study, frontal function in schizophrenic patients was analyzed by NIRS during random number generation (RNG), ruler-catching (RC), and sequential finger-to-thumb (SFT) tasks.

METHODS

Two sets of NIRS probes were attached to the foreheads of 13 schizophrenic patients and 10 control subjects approximately at Fp1-F7 and Fp2-F8. Near-infrared spectroscopy was conducted at a sampling rate of 1 Hz, with the pathlength being determined by time-resolved spectroscopy with differential pathlength factor measurements. The absolute changes in oxygenated (oxy-Hb) and deoxygenated (deoxy-Hb) hemoglobin concentrations in response to each task were measured, and total hemoglobin (total-Hb) concentration was calculated as the sum of the two.

RESULTS

During RNG task, total- and oxy-Hb concentrations increased, and deoxy-Hb decreased, but the responses were significantly smaller in schizophrenic patients. During RC task, oxy-Hb in schizophrenic patients tended to decrease, in contrast to the mostly increasing response in control subjects. No group difference was observed during SFT task.

CONCLUSIONS

Task-dependent profile of functional abnormalities was observed in schizophrenic frontal brain metabolism. These results support the usefulness of NIRS data in investigating frontal lobe dysfunction and evaluating psychopathologic condition in schizophrenic patients.

摘要

背景

先前的研究表明,近红外光谱(NIRS)具有高时间分辨率,几乎无需约束,适用于检查心理任务对脑循环的影响。在本研究中,通过NIRS分析了精神分裂症患者在随机数生成(RNG)、抓尺子(RC)和顺序拇指对指(SFT)任务期间的额叶功能。

方法

将两组NIRS探头分别大致贴在13名精神分裂症患者和10名对照受试者的额头Fp1 - F7和Fp2 - F8位置。近红外光谱以1 Hz的采样率进行,光程通过具有差分光程因子测量的时间分辨光谱法确定。测量了每项任务引起的氧合血红蛋白(oxy-Hb)和脱氧血红蛋白(deoxy-Hb)浓度的绝对变化,并计算总血红蛋白(total-Hb)浓度,即两者之和。

结果

在RNG任务期间,总血红蛋白和氧合血红蛋白浓度增加,脱氧血红蛋白浓度降低,但精神分裂症患者的反应明显较小。在RC任务期间,精神分裂症患者的氧合血红蛋白趋于降低,而对照受试者的反应大多是增加。在SFT任务期间未观察到组间差异。

结论

在精神分裂症患者额叶脑代谢中观察到功能异常的任务依赖性特征。这些结果支持了NIRS数据在研究额叶功能障碍和评估精神分裂症患者精神病理状况方面的有用性。

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