用近红外光谱法测量的小儿自闭症谱系障碍患者前额叶血流动力学反应降低。
Reduced prefrontal hemodynamic response in pediatric autism spectrum disorder measured with near-infrared spectroscopy.
作者信息
Uratani Mitsuhiro, Ota Toyosaku, Iida Junzo, Okazaki Kosuke, Yamamuro Kazuhiko, Nakanishi Yoko, Kishimoto Naoko, Kishimoto Toshifumi
机构信息
Department of Psychiatry, Manyo Hospital, Kashihara, Japan.
2Department of Psychiatry, Nara Medical University, 840 Shijyo-cho, Kashihara, Nara 634-8522 Japan.
出版信息
Child Adolesc Psychiatry Ment Health. 2019 Jun 28;13:29. doi: 10.1186/s13034-019-0289-9. eCollection 2019.
BACKGROUND
Functional neuroimaging studies suggest that prefrontal cortex dysfunction is present in people with autism spectrum disorder (ASD). Near-infrared spectroscopy is a noninvasive optical tool for examining oxygenation and hemodynamic changes in the cerebral cortex by measuring changes in oxygenated hemoglobin.
METHODS
Twelve drug-naïve male participants, aged 7-15 years and diagnosed with ASD according to DSM-5 criteria, and 12 age- and intelligence quotient (IQ)-matched healthy control males participated in the present study after giving informed consent. Relative concentrations of oxyhemoglobin were measured with frontal probes every 0.1 s during the Stroop color-word task, using 24-channel near-infrared spectroscopy.
RESULTS
Oxyhemoglobin changes during the Stroop color-word task in the ASD group were significantly smaller than those in the control group at channels 12 and 13, located over the dorsolateral prefrontal cortex (FDR-corrected P: 0.0021-0.0063).
CONCLUSION
The results suggest that male children with ASD have reduced prefrontal hemodynamic responses, measured with near-infrared spectroscopy.
背景
功能神经影像学研究表明，自闭症谱系障碍（ASD）患者存在前额叶皮质功能障碍。近红外光谱是一种非侵入性光学工具，通过测量氧合血红蛋白的变化来检测大脑皮质的氧合和血流动力学变化。
方法
12名未服用过药物的男性参与者，年龄在7至15岁之间，根据《精神疾病诊断与统计手册》第5版（DSM-5）标准被诊断为ASD，以及12名年龄和智商（IQ）匹配的健康对照男性在获得知情同意后参与了本研究。在Stroop颜色-文字任务期间，使用24通道近红外光谱仪，每隔0.1秒用前额探头测量氧合血红蛋白的相对浓度。
结果
在位于背外侧前额叶皮质的第12和13通道处，ASD组在Stroop颜色-文字任务期间的氧合血红蛋白变化明显小于对照组（经错误发现率校正的P值：0.0021 - 0.0063）。
结论
结果表明，用近红外光谱测量，患有ASD的男性儿童前额叶血流动力学反应降低。
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