Peretz Benjamin, Peretz Tamar
Department of Pediatric Dentistry, The Hebrew University Hadassah School of Dental Medicine, Jerusalem, Israel.
Pediatr Dent. 2003 Nov-Dec;25(6):601-4.
No standardized therapeutic interventions have been reported for patients diagnosed with breast cancer during pregnancy. A high risk for malformations in the fetus has been claimed when chemotherapy is administered during the first trimester of the pregnancy. Tooth formation of the primary teeth begins at 11 to 14 weeks of fetal life and is completed postnatally. Therefore, the teeth may be affected by insults during the second and third trimesters of pregnancy, thus acting as a sensitive parameter of possible placental transfer of chemotherapy. The cases presented describe the dental status of 2 young children whose mothers received chemotherapy for cancer during the third trimester of their pregnancies (adriamycin or adriamycin and cytoxan). Both women gave birth to healthy babies, born with full hair, normal blood counts, and birth weights (3.200 and 3.100 kgs). Dental examinations of both children (at ages 18 and 30 months) revealed sound teeth. It seems that adriamycin and cytoxan for cancer chemotherapy do not affect the primary teeth when administered in the third trimester of pregnancy.
对于在孕期被诊断出患有乳腺癌的患者，尚无标准化治疗干预措施的相关报道。若在妊娠头三个月进行化疗，胎儿出现畸形的风险较高。乳牙的牙胚形成始于胎儿期第11至14周，并在出生后完成。因此，乳牙可能在妊娠中期和晚期受到损害，从而成为化疗药物可能经胎盘转运的敏感指标。本文呈现的病例描述了2名幼儿的牙齿状况，他们的母亲在妊娠晚期因癌症接受了化疗（阿霉素或阿霉素与环磷酰胺联合使用）。两名女性均产下健康婴儿，出生时头发浓密、血常规正常、体重分别为3.200千克和3.100千克。对两名儿童（分别在18个月和30个月大时）进行的牙齿检查显示牙齿健康。看来，用于癌症化疗的阿霉素和环磷酰胺在妊娠晚期使用时不会影响乳牙。
