Wobbes M H, de Groot M R, Brons J T, Smit W M
Afd. Interne Geneeskunde, Medisch Spectrum Twente, Postbus 50.000, 7500 KA Enschede.
Ned Tijdschr Geneeskd. 2004 Feb 21;148(8):349-52.
Two women aged 34 and 32, were diagnosed with cancer during pregnancy. The 34-year-old woman with breast cancer diagnosed during the first trimester of pregnancy, had just undergone breast-conserving surgery. She chose to have an abortion before adjuvant chemotherapy was started. A year after chemotherapy ended she became pregnant again and gave birth to a healthy child. After 3 years there were no signs of metastases. In the 32-year-old woman with a malignant lymphoma diagnosed during the third trimester of pregnancy, chemotherapy had to be started because she developed V. cava superior syndrome. The dyspnoea disappeared and a week after the first treatment she gave birth to a healthy child. A year after completion of treatment she was in complete remission and her child was developing well. Pregnancy is not always a contraindication for starting chemotherapy. However, in order to reduce the risk to mother and child as much as possible, the duration of the pregnancy as well as different groups of cytostatic drugs have to be taken into consideration. A multidisciplinary approach to mother and child is essential.
两名年龄分别为34岁和32岁的女性在怀孕期间被诊断出患有癌症。34岁的女性在怀孕早期被诊断出患有乳腺癌，刚刚接受了保乳手术。她选择在开始辅助化疗前进行人工流产。化疗结束一年后，她再次怀孕并生下了一个健康的孩子。三年后没有转移迹象。32岁的女性在怀孕晚期被诊断出患有恶性淋巴瘤，由于出现上腔静脉综合征，不得不开始化疗。呼吸困难消失，首次治疗一周后她生下了一个健康的孩子。治疗完成一年后，她完全缓解，孩子发育良好。怀孕并不总是开始化疗的禁忌症。然而，为了尽可能降低对母婴的风险，必须考虑怀孕时间以及不同类别的细胞毒性药物。对母婴采取多学科方法至关重要。
