Navas-Martin Sonia, Weiss Susan R
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6076, USA.
Viral Immunol. 2003;16(4):461-74. doi: 10.1089/088282403771926292.
The identification of a new coronavirus as the etiological agent of severe acute respiratory syndrome (SARS) has evoked much new interest in the molecular biology and pathogenesis of coronaviruses. This review summarizes present knowledge on coronavirus molecular biology and pathogenesis with particular emphasis on mouse hepatitis virus (MHV). MHV, a member of coronavirus group 2, is a natural pathogen of the mouse; MHV infection of the mouse is considered one of the best models for the study of demyelinating disease, such as multiple sclerosis, in humans. As a result of the SARS epidemic, coronaviruses can now be considered as emerging pathogens. Future research on SARS needs to be based on all the knowledge that coronavirologists have generated over more than 30 years of research.
一种新型冠状病毒被确认为严重急性呼吸综合征（SARS）的病原体，这引发了人们对冠状病毒分子生物学和发病机制的新兴趣。本综述总结了目前关于冠状病毒分子生物学和发病机制的知识，特别强调了小鼠肝炎病毒（MHV）。MHV是冠状病毒第2组的成员，是小鼠的天然病原体；小鼠感染MHV被认为是研究人类脱髓鞘疾病（如多发性硬化症）的最佳模型之一。由于SARS疫情，冠状病毒现在可被视为新兴病原体。未来对SARS的研究需要基于冠状病毒学家在30多年研究中积累的所有知识。
