与脑膜炎奈瑟菌和乳糖奈瑟菌交叉反应的卡他莫拉菌外膜抗原分析。
Analysis of Moraxella catarrhalis outer membrane antigens cross-reactive with Neisseria meningitidis and Neisseria lactamica.
作者信息
Troncoso Gemma, Sánchez Sandra, Criado María Teresa, Ferreirós Carlos
机构信息
Departamento de Microbiología, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
出版信息
FEMS Immunol Med Microbiol. 2004 Jan 15;40(1):89-94. doi: 10.1016/S0928-8244(03)00298-0.
Mouse sera against outer membrane proteins from Moraxella catarrhalis, Neisseria meningitidis and Neisseria lactamica, and human sera from both healthy individuals and patients convalescing from meningococcal meningitis were used to identify cross-reactive antigens. Mouse anti-N. meningitidis and anti-N. lactamica sera recognized 77, 62 and 32 kDa outer membrane antigens in M. catarrhalis strains; on the contrary, the meningococcal porin PorB (38-42 kDa) was recognized by one of the two anti-M. catarrhalis sera. Human sera from both healthy individuals and patients convalescing from meningococcal meningitis also showed cross-reactive antibodies against these proteins. The existence of cross-reactive antigens in M. catarrhalis and N. meningitidis (as well as in N. lactamica) could favor the development of natural immunization against both pathogens.
使用针对卡他莫拉菌、脑膜炎奈瑟菌和乳酸奈瑟菌外膜蛋白的小鼠血清，以及来自健康个体和正在从脑膜炎球菌性脑膜炎康复的患者的人血清来鉴定交叉反应性抗原。小鼠抗脑膜炎奈瑟菌和抗乳酸奈瑟菌血清识别出卡他莫拉菌菌株中的77 kDa、62 kDa和32 kDa外膜抗原；相反，两种抗卡他莫拉菌血清之一识别出脑膜炎球菌孔蛋白PorB（38 - 42 kDa）。来自健康个体和正在从脑膜炎球菌性脑膜炎康复的患者的人血清也显示出针对这些蛋白的交叉反应性抗体。卡他莫拉菌和脑膜炎奈瑟菌（以及乳酸奈瑟菌）中交叉反应性抗原的存在可能有利于针对这两种病原体的天然免疫的发展。
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