Troncoso G, Sánchez S, Criado M T, Ferreirós C M
Departamento de Microbiología, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain.
FEMS Immunol Med Microbiol. 2002 Sep 6;34(1):9-15. doi: 10.1111/j.1574-695X.2002.tb00597.x.
Sera from healthy human volunteers, patients convalescent from meningococcal meningitis, and mice immunized with outer membrane proteins from Neisseria meningitidis and Neisseria lactamica strains were used to analyze and identify antigens cross-reactive to both neisserial species. All classes of meningococcal proteins except class 1 (PorA) and class 5 cross-reacted with N. lactamica proteins and two other proteins of 65 and 55 kDa (an iron-regulated protein). Results obtained with the mouse sera demonstrate that cross-reactive antibodies can be elicited by either N. meningitidis or N. lactamica. These results support the suggestion that N. lactamica contributes to the development of natural immunity against N. meningitidis during the first years of life. The use of vaccines containing proteins other than PorA could interfere in colonization of mucosal surfaces by N. lactamica, hampering the natural mechanisms of immunity acquisition in humans. Only convalescent sera reacted with the 55 and 65 kDa proteins, which suggests that they might be relevant for pathogenicity.
来自健康人类志愿者、从脑膜炎球菌性脑膜炎康复的患者以及用脑膜炎奈瑟菌和乳酸奈瑟菌菌株的外膜蛋白免疫的小鼠的血清，用于分析和鉴定与这两种奈瑟菌属物种均发生交叉反应的抗原。除1类（PorA）和5类之外的所有脑膜炎球菌蛋白均与乳酸奈瑟菌蛋白以及另外两种65 kDa和55 kDa的蛋白（一种铁调节蛋白）发生交叉反应。从小鼠血清获得的结果表明，脑膜炎奈瑟菌或乳酸奈瑟菌均可引发交叉反应性抗体。这些结果支持了以下观点：乳酸奈瑟菌有助于在生命的最初几年中针对脑膜炎奈瑟菌形成天然免疫力。使用含有PorA以外蛋白质的疫苗可能会干扰乳酸奈瑟菌在粘膜表面的定植，从而阻碍人类获得免疫的天然机制。只有康复期血清与55 kDa和65 kDa的蛋白发生反应，这表明它们可能与致病性有关。
