Markand Omkar N
Department of Neurology, Indiana University School of Medicine, University Hospital Room 1711, 550 North University Boulevard, Indianapolis, IN 46202, USA.
J Clin Neurophysiol. 2003 Nov-Dec;20(6):426-41. doi: 10.1097/00004691-200311000-00005.
Lennox-Gastaut syndrome (LGS) is a childhood epileptic encephalopathy characterized by an electroclinical triad of generalized slow spike wave (SSW) activity in the EEG, multiple types of epileptic seizures, and slow mental development. It is usually subdivided into symptomatic and cryptogenic types, the latter accounting for at least one fourth of all patients. Symptomatic cases are due to diverse cerebral conditions, which are usually bilateral, diffuse, or multifocal, involving cerebral gray matter. Twenty percent of all patients with LGS have prior infantile spasms with hypsarrythmia. The characteristic interictal EEG pattern of LGS is 1.5 to 2.5 Hz SSW activity, which is bilaterally synchronous, dominant over the frontocentral regions, and usually symmetric. There are varying degrees of slowing of the background. Sleep discloses paroxysms of generalized fast (10 to 25 Hz) rhythmic activity.
伦诺克斯 - 加斯托综合征（LGS）是一种儿童期癫痫性脑病，其特征为脑电图中出现广泛性慢棘波（SSW）活动、多种类型的癫痫发作以及智力发育迟缓这一电临床三联征。它通常分为症状性和隐源性类型，后者至少占所有患者的四分之一。症状性病例由多种脑部疾病引起，这些疾病通常为双侧性、弥漫性或多灶性，累及脑灰质。所有LGS患者中有20%既往有婴儿痉挛伴高峰节律紊乱。LGS的特征性发作间期脑电图模式为1.5至2.5赫兹的SSW活动，双侧同步，额中央区占优势，且通常对称。背景活动有不同程度的减慢。睡眠时可出现广泛性快速（10至25赫兹）节律性活动的阵发性发作。
