Iacopetta B, Grieu F, Joseph D
School of Surgery and Pathology, University of Western Australia, Nedlands 6009, Australia.
Br J Cancer. 2004 Jan 26;90(2):419-22. doi: 10.1038/sj.bjc.6601545.
Serum and tissue levels of interleukin-6 (IL-6) have been implicated in the biological phenotype of breast carcinoma. A common G/C polymorphism at position -174 of the IL-6 promoter can influence the expression level of this gene. We therefore investigated for associations between this polymorphism and various phenotypic features in a series of 256 breast cancers. Individuals who were homozygous for the C allele (n=55) were more likely to have higher-grade tumours (P=0.039) with ductal histology (P=0.030) compared to those harbouring at least one wild-type G allele (n=201). Homozygosity for the C allele was also associated with significantly worse overall survival (P=0.031). We conclude that the -174 C allele of IL-6 is associated with a more aggressive breast cancer phenotype.
白细胞介素-6（IL-6）的血清和组织水平与乳腺癌的生物学表型有关。IL-6启动子-174位常见的G/C多态性可影响该基因的表达水平。因此，我们在256例乳腺癌患者中研究了这种多态性与各种表型特征之间的关联。与至少携带一个野生型G等位基因的个体（n = 201）相比，C等位基因纯合子个体（n = 55）更有可能患有组织学类型为导管癌的高级别肿瘤（P = 0.039）（P = 0.030）。C等位基因纯合性也与总体生存率显著较差相关（P = 0.031）。我们得出结论，IL-6的-174 C等位基因与更具侵袭性的乳腺癌表型相关。
