甲状腺功能亢进症患者尿吡啶啉和脱氧吡啶啉排泄的定量分析。

Quantitative analyses of urinary pyridinoline and deoxypyridinoline excretion in patients with hyperthyroidism.

作者信息

Ohishi T, Takahashi M, Kushida K, Horiuchi K, Ishigaki S, Inoue T

机构信息

Department of Orthopedic Surgery, Hamamatsu University School of Medicine, Shizuoka, Japan.

出版信息

Endocr Res. 1992;18(4):281-90. doi: 10.1080/07435809209111037.

DOI:10.1080/07435809209111037

PMID:1473521

Abstract

It is well established that bone turnover increases and bone resorption exceeds bone formation in patients with hyperthyroidism. Recently, urinary pyridinoline and deoxypyridinoline have been employed as indicators of bone resorption. In this study, urinary pyridinoline and deoxypyridinoline levels in fourteen female patients with untreated hyperthyroidism were measured and compared with levels in 134 healthy females. Values of urinary pyridinoline and deoxypyridinoline were significantly higher than in age-matched controls. Moreover, values of serum free triiodothyronine correlated with urinary pyridinoline (r = 0.769, p < 0.01), and urinary deoxypyridinoline (r = 0.799, p < 0.001) in patients with hyperthyroidism.

摘要

众所周知，甲状腺功能亢进患者的骨转换增加，骨吸收超过骨形成。最近，尿吡啶啉和脱氧吡啶啉已被用作骨吸收的指标。在本研究中，测量了14例未经治疗的甲状腺功能亢进女性患者的尿吡啶啉和脱氧吡啶啉水平，并与134例健康女性的水平进行了比较。尿吡啶啉和脱氧吡啶啉的值显著高于年龄匹配的对照组。此外，甲状腺功能亢进患者的血清游离三碘甲状腺原氨酸值与尿吡啶啉（r = 0.769，p < 0.01）和尿脱氧吡啶啉（r = 0.799，p < 0.001）相关。