Li Wenzhi, Zhang Weiqiang, Zhao Quanyi, Li Yongmin, Ma Chunlin, Chen Liren, Yin Yuanqi
Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Tianshui Road 342, 730000, Lanzhou, P.R. China.
Anal Bioanal Chem. 2004 Mar;378(5):1364-8. doi: 10.1007/s00216-003-2396-x. Epub 2004 Jan 21.
The enantioseparation of seven novel chiral transition metal tetrahedral clusters has been achieved for the first time on cellulose derivatized with tris(3,5-dimethylphenylcarbamate) (CDMPC) as chiral stationary phase (CSP) and hexane containing different alcohols as modifiers as mobile phases. The effect of mobile-phase composition on enantioselectivity was studied, and the effect of structural variation of the solutes on their enantioseparation was also investigated. It was found that both the metal in the tetrahedral core and the ligand coordinated to the atom in the tetrahedral core had significant effects on the chromatographic behavior of the analytes.
首次以三（3,5-二甲基苯基氨基甲酸酯）（CDMPC）衍生化的纤维素为手性固定相（CSP），以含不同醇类的正己烷为改性剂作为流动相，实现了七种新型手性过渡金属四面体簇的对映体分离。研究了流动相组成对对映选择性的影响，还考察了溶质结构变化对其对映体分离的影响。发现四面体核中的金属以及与四面体核中原子配位的配体对分析物的色谱行为都有显著影响。
