5-羟色胺4受体存在于仔猪心房且对SDZ 205-557敏感，但在乳头肌中不存在。
5-HT4 receptors, present in piglet atria and sensitive to SDZ 205-557, are absent in papillary muscle.
作者信息
Lorrain J, Grosset A, O'Connor S E
机构信息
Synthélabo Recherche (L.E.R.S.), Department of Biology, Bagneux, France.
出版信息
Eur J Pharmacol. 1992 Dec 8;229(1):105-8. doi: 10.1016/0014-2999(92)90293-d.
Putative 5-HT4 receptors were investigated in isolated piglet left atria and papillary muscles. In atrial tissues, 5-hydroxytryptamine (5-HT) was a potent positive inotropic agent with a pD2 of 6.7. Its effects were antagonised in a selective and competitive manner by the 5-HT4 receptor antagonist, SDZ 205-557, with a pA2 of 7.3. In contrast to atrial tissues, piglet papillary muscles were virtually unresponsive to 5-HT 10(-8)-10(-3) M, suggesting that functional cardiac 5-HT4 receptors are not present in ventricular tissue.
在离体仔猪左心房和乳头肌中研究了假定的5-羟色胺4（5-HT4）受体。在心房组织中，5-羟色胺（5-HT）是一种强效的正性肌力剂，其解离常数负对数（pD2）为6.7。其作用被5-HT4受体拮抗剂SDZ 205-557以选择性和竞争性方式拮抗，其拮抗常数负对数（pA2）为7.3。与心房组织相反，仔猪乳头肌对10^(-8)-10^(-3)M的5-HT几乎无反应，提示心室组织中不存在功能性心脏5-HT4受体。
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