Waltman Nancy L, Twiss Janice J, Ott Carol D, Gross Gloria Jean, Lindsey Ada M, Moore Timothy E, Berg Kris
University of Nebraska Medical Center, College of Nursing, P.O. Box 880620, Lincoln, NE 68588-0620, USA.
J Nurs Scholarsh. 2003;35(4):333-8. doi: 10.1111/j.1547-5069.2003.00333.x.
To test a 12-month multicomponent intervention for preventing or treating osteoporosis in 21 postmenopausal women who had completed treatment (except Tamoxifen) for breast cancer, and for whom hormone replacement therapy (HRT) was contraindicated.
Pilot intervention study.
The intervention consisted of home-based strength and weight training exercises, 5 or 10 mg alendronate per day, 1500 mg calcium per day, 400 IU vitamin D per day, education on osteoporosis, and facilitative strategies to promote adherence to the intervention. Outcome measures were: adherence to the intervention, dynamic balance, muscle strength, and bone mineral density (BMD) of the hip, spine, and forearm.
Adherence to calcium, vitamin D, and alendronate therapy was above 95%, and adherence to strength training exercises was above 85%. Over the 12 months, the 21 participants had significant improvements in dynamic balance, muscle strength for hip flexion, hip extension, and knee flexion, and BMD of the spine and hip. Participants had a significant decrease in BMD of the forearm. Three of the 21 women who had measurable bone loss at baseline had normal BMD after 12 months of the intervention.
对21名已完成乳腺癌治疗（他莫昔芬除外）且激素替代疗法（HRT）禁忌的绝经后女性进行为期12个月的多组分干预，以预防或治疗骨质疏松症。
试点干预研究。
干预措施包括居家力量和体重训练运动、每天5或10毫克阿仑膦酸钠、每天1500毫克钙、每天400国际单位维生素D、骨质疏松症教育以及促进干预依从性的策略。结局指标包括：干预的依从性、动态平衡、肌肉力量以及髋部、脊柱和前臂的骨密度（BMD）。
钙、维生素D和阿仑膦酸钠治疗的依从性高于95%，力量训练运动的依从性高于85%。在12个月期间，21名参与者在动态平衡、髋部屈曲、髋部伸展和膝关节屈曲的肌肉力量以及脊柱和髋部的骨密度方面有显著改善。参与者的前臂骨密度显著降低。21名在基线时有可测量骨质流失的女性中有3名在干预12个月后骨密度正常。
