Shimizu H, Sakano T, Fujie A, Nishimura S, Ueda K
Department of Pediatrics, Hiroshima University School of Medicine, Japan.
Experientia. 1992 Dec 1;48(11-12):1148-50. doi: 10.1007/BF01948011.
The effect of interleukin 1 beta (IL-1 beta), interferon gamma (IFN-gamma), tumor necrosis factor alpha (TNF alpha) and lipopolysaccharide (LPS) on the expression of the C2 and C3 genes in human adherent monocytes was studied. Stimulation of monocytes with IFN-gamma increased both C2 and C3 mRNA. IL-1 beta also increased C2 mRNA level, whereas C3 gene expression was not enhanced. TNF alpha failed to increase either C2 or C3 mRNA. LPS increased C2 mRNA, but suppressed C3 gene expression. These results suggest that C2 and C3 production by monocytes is regulated by IL-1 beta and IFN-gamma in the local tissues.
研究了白细胞介素1β（IL-1β）、干扰素γ（IFN-γ）、肿瘤坏死因子α（TNFα）和脂多糖（LPS）对人贴壁单核细胞中C2和C3基因表达的影响。用IFN-γ刺激单核细胞可增加C2和C3 mRNA。IL-1β也增加C2 mRNA水平，而C3基因表达未增强。TNFα未能增加C2或C3 mRNA。LPS增加C2 mRNA，但抑制C3基因表达。这些结果表明，单核细胞产生C2和C3受局部组织中的IL-1β和IFN-γ调节。
