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Large doses of major surface glycoprotein-sensitized donor splenocytes transferred to corticosteroid treated rats with Pneumocystis pneumonia result in successful reduction of organism burden.

作者信息

Thullen Timothy D, Walzer Peter D

机构信息

Veterans Affairs Medical Center, and the Division of Infectious Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, USA.

出版信息

J Eukaryot Microbiol. 2003;50 Suppl:666-7. doi: 10.1111/j.1550-7408.2003.tb00677.x.

DOI:10.1111/j.1550-7408.2003.tb00677.x
PMID:14736210
Abstract
摘要

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1
Large doses of major surface glycoprotein-sensitized donor splenocytes transferred to corticosteroid treated rats with Pneumocystis pneumonia result in successful reduction of organism burden.将大剂量主要表面糖蛋白致敏的供体脾细胞转移到患有卡氏肺孢子虫肺炎且接受了皮质类固醇治疗的大鼠体内，可成功减轻病原体负荷。
J Eukaryot Microbiol. 2003;50 Suppl:666-7. doi: 10.1111/j.1550-7408.2003.tb00677.x.
2
Adoptive transfer of specific lymphocyte populations sensitized to the major surface glycoprotein of Pneumocystis carinii decreases organism burden while increasing survival rate in the rat.将对卡氏肺孢子虫主要表面糖蛋白致敏的特定淋巴细胞群体进行过继转移，可降低大鼠体内的病原体负荷，同时提高其存活率。
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Adoptive transfer of lymphocytes sensitized to the major surface glycoprotein of Pneumocystis carinii confers protection in the rat.将对卡氏肺孢子虫主要表面糖蛋白致敏的淋巴细胞进行过继转移可使大鼠获得保护。
J Clin Invest. 1995 Jun;95(6):2587-93. doi: 10.1172/JCI117960.
4
Immunization with recombinant Pneumocystis carinii p55 antigen provides partial protection against infection: characterization of epitope recognition associated with immunization.用重组卡氏肺孢子虫p55抗原免疫可提供部分抗感染保护：与免疫相关的表位识别特征
Microbes Infect. 2000 Feb;2(2):127-36. doi: 10.1016/s1286-4579(00)00275-6.
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Western blot analysis of rat Pneumocystis carinii antigens using convalescent rat sera and rabbit anti-gp120.使用恢复期大鼠血清和兔抗gp120对大鼠卡氏肺孢子虫抗原进行蛋白质印迹分析。
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6
Recombinant major surface glycoprotein of Pneumocystis carinii elicits a specific immune response but is not protective in immunosuppressed rats.卡氏肺孢子虫重组主要表面糖蛋白可引发特异性免疫反应，但对免疫抑制大鼠无保护作用。
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Production and characterization of monoclonal antibodies specific for the major surface glycoprotein of Pneumocystis carinii.卡氏肺孢子虫主要表面糖蛋白特异性单克隆抗体的制备与鉴定
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Immunization with the major surface glycoprotein of Pneumocystis carinii elicits a protective response.用卡氏肺孢子虫主要表面糖蛋白进行免疫可引发保护性反应。
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Immunization with Pneumocystis carinii gpA is immunogenic but not protective in a mouse model of P. carinii pneumonia.用卡氏肺孢子虫糖蛋白A进行免疫接种在卡氏肺孢子虫肺炎小鼠模型中具有免疫原性，但无保护作用。
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10
In vitro cytolytic activity of lymphocytes against Pneumocystis carinii.淋巴细胞对卡氏肺孢子虫的体外细胞溶解活性。
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