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Adoptive transfer of specific lymphocyte populations sensitized to the major surface glycoprotein of Pneumocystis carinii decreases organism burden while increasing survival rate in the rat.

作者信息

Theus S A, Walzer P D

机构信息

Department of Internal Medicine, University of Cincinnati, Ohio 45267, USA.

出版信息

J Eukaryot Microbiol. 1997 Nov-Dec;44(6):23S-24S. doi: 10.1111/j.1550-7408.1997.tb05750.x.

DOI:10.1111/j.1550-7408.1997.tb05750.x
PMID:9508414
Abstract
摘要

相似文献

1
Adoptive transfer of specific lymphocyte populations sensitized to the major surface glycoprotein of Pneumocystis carinii decreases organism burden while increasing survival rate in the rat.将对卡氏肺孢子虫主要表面糖蛋白致敏的特定淋巴细胞群体进行过继转移，可降低大鼠体内的病原体负荷，同时提高其存活率。
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Adoptive transfer of lymphocytes sensitized to the major surface glycoprotein of Pneumocystis carinii confers protection in the rat.将对卡氏肺孢子虫主要表面糖蛋白致敏的淋巴细胞进行过继转移可使大鼠获得保护。
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Large doses of major surface glycoprotein-sensitized donor splenocytes transferred to corticosteroid treated rats with Pneumocystis pneumonia result in successful reduction of organism burden.将大剂量主要表面糖蛋白致敏的供体脾细胞转移到患有卡氏肺孢子虫肺炎且接受了皮质类固醇治疗的大鼠体内，可成功减轻病原体负荷。
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In vitro cytolytic activity of lymphocytes against Pneumocystis carinii.淋巴细胞对卡氏肺孢子虫的体外细胞溶解活性。
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Immunization with recombinant Pneumocystis carinii p55 antigen provides partial protection against infection: characterization of epitope recognition associated with immunization.用重组卡氏肺孢子虫p55抗原免疫可提供部分抗感染保护：与免疫相关的表位识别特征
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B Lymphocytes Are Required during the Early Priming of CD4+ T Cells for Clearance of Pneumocystis Infection in Mice.清除小鼠肺孢子菌感染时，CD4+ T细胞早期启动阶段需要B淋巴细胞。
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Western blot analysis of rat Pneumocystis carinii antigens using convalescent rat sera and rabbit anti-gp120.使用恢复期大鼠血清和兔抗gp120对大鼠卡氏肺孢子虫抗原进行蛋白质印迹分析。
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引用本文的文献

1
Sensitized splenocytes result in deleterious cytokine cascade and hyperinflammatory response in rats with Pneumocystis pneumonia despite the presence of corticosteroids.尽管存在皮质类固醇，但致敏脾细胞会在卡氏肺孢子虫肺炎大鼠中引发有害的细胞因子级联反应和过度炎症反应。
Infect Immun. 2004 Feb;72(2):757-65. doi: 10.1128/IAI.72.2.757-765.2004.
2
New rat model of Pneumocystis pneumonia induced by anti-CD4(+) T-lymphocyte antibodies.抗CD4(+) T淋巴细胞抗体诱导的新型大鼠肺孢子菌肺炎模型
Infect Immun. 2003 Nov;71(11):6292-7. doi: 10.1128/IAI.71.11.6292-6297.2003.
3
Genetics of surface antigen expression in Pneumocystis carinii.
卡氏肺孢子虫表面抗原表达的遗传学
Infect Immun. 2001 Feb;69(2):627-39. doi: 10.1128/IAI.69.2.627-639.2001.
4
Immunological features of Pneumocystis carinii infection in humans.卡氏肺孢子虫感染在人类中的免疫学特征。
Clin Diagn Lab Immunol. 1999 Mar;6(2):149-55. doi: 10.1128/CDLI.6.2.149-155.1999.