Vergote I, Larsen R H, De Vos L, Winderen M, Ellingsen T, Bjørgum J, Hoff P, Aas M, Tropé C, Nustad K
Department of Gynecologic Oncology, Norwegian Radium Hospital, Oslo.
Gynecol Oncol. 1992 Dec;47(3):358-65. doi: 10.1016/0090-8258(92)90140-e.
The alpha-emitter 211At was bound to polymer microspheres with a diameter of 1.8 microns. The distributions in mice of intraperitoneally injected 211At microspheres, 90Y silicate colloid, and 32P chromic phosphate colloid were compared. The microspheres with 211At spread rapidly in the peritoneal cavity and remained mainly on the intraperitoneal surfaces. Intraperitoneal injection of 90Y colloid resulted in high levels in intraperitoneal fat and the diaphragm, but 1 day after injection 8.5% of the injected dose per gram was found in blood and after 6 days 2.5% was observed in bone. The highest accumulation of 32P was found in liver and spleen. The injection of additional nonradioactive chromic phosphate colloid resulted in an even higher accumulation of 32P in spleen and liver. The same phenomenon was not observed with 211At microspheres. It is suggested that it is not only the particle size which is important in the distribution of intraperitoneally injected colloid, but the amount of colloid, the type of colloid, the addition or presence of other substances such as ascites, and the animal species might also influence the distribution. In conclusion, the intraperitoneal distribution of 211At-labeled microspheres in mice was favorable compared with 90Y and 32P colloid. These data must be viewed cautiously since the distribution might be different in other animal species or humans.
α发射体砹-211被结合到直径为1.8微米的聚合物微球上。比较了腹腔注射砹-211微球、钇-90硅酸盐胶体和磷-32铬酸磷酸盐胶体在小鼠体内的分布情况。含砹-211的微球在腹腔内迅速扩散，主要停留在腹膜表面。腹腔注射钇-90胶体后，腹腔脂肪和横膈膜中含量较高，但注射后1天，每克血液中发现注射剂量的8.5%，6天后在骨骼中发现2.5%。磷-32在肝脏和脾脏中的蓄积量最高。注射额外的非放射性铬酸磷酸盐胶体导致磷-32在脾脏和肝脏中的蓄积量更高。砹-211微球未观察到同样的现象。提示腹腔注射胶体的分布不仅与粒径有关，胶体的量、胶体的类型、其他物质如腹水的添加或存在以及动物种类也可能影响分布。总之，与钇-90和磷-32胶体相比，砹-211标记的微球在小鼠体内的腹腔分布较好。由于在其他动物物种或人类中分布可能不同，这些数据必须谨慎看待。
