Zubillaga M B, Boccio J R, Nicolini J O, Ughetti R, Lanari E, Caro R A
Radioisotope Laboratory, Facultad de Farmacia y Bioquímica, U.B.A., Buenos Aires, Argentina.
Nucl Med Biol. 1996 Oct;23(7):907-10. doi: 10.1016/s0969-8051(96)00123-0.
In order to evaluate the effectiveness of an intratumorally single dose of chromic [32P] phosphate for the treatment of solid tumors, studies of bioelimination, biodistribution, and therapeutic action were carried out. Only for comparative purposes were similar studies undertaken using a solution of sodium [32P] orthophosphate-gelatin. Results show that when sodium [32P] orthophosphate-gelatin was intratumorally injected, the percentage of total elimination, after 32 days of treatment, was equal to 85.90 +/- 8.70%, with a higher percentage in urine (64.50 +/- 13.70%) than in feces (21.40 +/- 4.50%). In biodistribution studies, the greater percentage was found in bone (15.54 +/- 2.21%), whereas only 2.51 +/- 0.39% remained in the tumor. When chromic [32P] phosphate was intratumorally injected, we found that the total elimination was equal to 51.70 +/- 6.90%, with a higher amount in feces (32.70 +/- 4.80%) than in urine (19.00 +/- 3.60%). Biodistribution studies demonstrated that 28.93 +/- 1.30% was still in the tumor and 19.01 +/- 1.30% of the injected activity was found in the liver. On the other hand, when therapeutic action was evaluated, no tumoral regression was observed. These results demonstrate that the colloid of chromic [32P] phosphate cannot be used in the treatment of solid tumors as it mobilizes from the injection point, delivering a high dose to the entire organism.
为了评估瘤内单次注射铬[32P]磷酸盐治疗实体瘤的有效性，开展了生物消除、生物分布及治疗作用的研究。仅为比较目的，采用[32P]正磷酸钠-明胶溶液进行了类似研究。结果显示，瘤内注射[32P]正磷酸钠-明胶后，治疗32天后的总消除百分比为85.90±8.70%，尿液中的百分比（64.50±13.70%）高于粪便中的百分比（21.40±4.50%）。在生物分布研究中，发现骨中的百分比最高（15.54±2.21%），而肿瘤中仅残留2.51±0.39%。瘤内注射铬[32P]磷酸盐时，我们发现总消除率为51.70±6.90%，粪便中的量（32.70±4.80%）高于尿液中的量（19.00±3.60%）。生物分布研究表明，仍有28.93±1.30%在肿瘤中，且在肝脏中发现了19.01±1.30%的注入活性。另一方面，在评估治疗作用时，未观察到肿瘤消退。这些结果表明，铬[32P]磷酸盐胶体不能用于治疗实体瘤，因为它会从注射点移动，给整个机体带来高剂量。
