Casey Mike, Keaveney Claire M
Chemistry Department, the Centre for Synthesis and Chemical Biology, and the Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland.
Chem Commun (Camb). 2004 Jan 21(2):184-5. doi: 10.1039/b312245j. Epub 2003 Dec 5.
A short stereoselective formal total synthesis of (+/-)-podophyllotoxin has been carried out from a sulfoxide, using a one-pot tandem conjugate addition/aldol/electrophilic aromatic substitution reaction to form a tetralin, which was converted into picropodophyllin in two steps.
以亚砜为原料，通过一锅串联共轭加成/羟醛缩合/亲电芳香取代反应合成四氢萘，经两步反应将其转化为苦鬼臼脂素，完成了（±）-鬼臼毒素的简短立体选择性形式全合成。
