利用亚砜化学对（±）-鬼臼毒素进行简洁的立体控制形式全合成。
A concise stereocontrolled formal total synthesis of (+/-)-podophyllotoxin using sulfoxide chemistry.
作者信息
Casey Mike, Keaveney Claire M
机构信息
Chemistry Department, the Centre for Synthesis and Chemical Biology, and the Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland.
出版信息
Chem Commun (Camb). 2004 Jan 21(2):184-5. doi: 10.1039/b312245j. Epub 2003 Dec 5.
DOI:10.1039/b312245j
PMID:14737540
Abstract
A short stereoselective formal total synthesis of (+/-)-podophyllotoxin has been carried out from a sulfoxide, using a one-pot tandem conjugate addition/aldol/electrophilic aromatic substitution reaction to form a tetralin, which was converted into picropodophyllin in two steps.
摘要
以亚砜为原料，通过一锅串联共轭加成/羟醛缩合/亲电芳香取代反应合成四氢萘，经两步反应将其转化为苦鬼臼脂素，完成了（±）-鬼臼毒素的简短立体选择性形式全合成。
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