有机合成中的硅宾：（±）-表鬼臼毒素的简洁合成
Silenes in organic synthesis: a concise synthesis of (+/-) -epi-picropodophyllin.
作者信息
Pullin Robert D C, Sellars Jonathan D, Steel Patrick G
机构信息
Department of Chemistry, University of Durham, Science Laboratories, Durham, UK.
出版信息
Org Biomol Chem. 2007 Oct 7;5(19):3201-6. doi: 10.1039/b710370k. Epub 2007 Aug 31.
DOI:10.1039/b710370k
PMID:17878979
Abstract
A concise, seven step synthesis of the aryl tetralin lignan lactone epi-picropodophyllin from piperonal is described. The key steps are a silene diene Diels-Alder reaction and the Hosomi-Sakurai reaction of the resultant silacyclohexene.
摘要
本文描述了一种从胡椒醛出发简洁的、七步合成芳基四氢萘木脂素内酯表鬼臼毒素的方法。关键步骤是硅烯二烯的狄尔斯-阿尔德反应以及所得硅杂环己烯的细见-樱井反应。
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