Maciorkowska E, Kaczmarski M, Kemona A, Kondej-Muszyńska K, Gocał M
III Department of Children's Diseases, Medical University of Białystok, 15-274 Białystok, J. Waszyngtona 17 (PL).
Rocz Akad Med Bialymst. 2003;48:100-4.
Helicobacter pylori colonization of gastric epithelium causes a local and systemic, cellular and humoral immune response. Despite this immune response involvement in the infection, its elimination from the organism does not take place and the process usually becomes chronic. The purpose of the study was to establish the prevalence of gastric mucosa inflammation in children and adults with serum positive anti-Helicobacter pylori antibodies IgG.
The study included 171 patients comprising 109 (63.7%) children and 62 (36.3%) adults with IgG positive titre against Helicobacter pylori, who were qualified to the study basing on epidemiological examinations estimating the prevalence of Helicobacter pylori infection in the population of north-eastern Poland living in the country, town and city. All patients reported dyspeptic symptoms. The evaluation was performed basing on the morphological (endoscopy) and histopathological examinations estimating the changes in gastric mucosa of these patients.
The evaluation of antrum and corpus gastric mucosa proved normal gastric mucosa in 34 children (31.1%) and 10 adults (16.1%) with positive IgG antibodies against Helicobacter pylori. The evaluation of the severity showed the predominance of moderate inflammation within corpus in children (37.6%) and marked inflammation in adults (45.1%).
The concentration of IgG antibodies against Helicobacter pylori in both groups was highest in patients with marked antrum gastric mucosa inflammation.
胃上皮细胞的幽门螺杆菌定植会引发局部和全身的细胞及体液免疫反应。尽管这种免疫反应参与了感染过程，但幽门螺杆菌并未从机体中被清除，感染过程通常会转为慢性。本研究的目的是确定血清抗幽门螺杆菌抗体IgG呈阳性的儿童和成人胃黏膜炎症的患病率。
该研究纳入了171名患者，其中109名（63.7%）为儿童，62名（36.3%）为成人，他们的抗幽门螺杆菌IgG滴度呈阳性，这些患者是根据对波兰东北部农村、城镇和城市人口中幽门螺杆菌感染患病率的流行病学调查而入选本研究的。所有患者均有消化不良症状。评估基于形态学（内镜检查）和组织病理学检查，以评估这些患者胃黏膜的变化。
对胃窦和胃体黏膜的评估显示，34名（31.1%）抗幽门螺杆菌IgG抗体呈阳性的儿童和10名（16.1%）成人的胃黏膜正常。严重程度评估显示，儿童胃体中以中度炎症为主（37.6%），成人中以重度炎症为主（45.1%）。
两组中抗幽门螺杆菌IgG抗体浓度在胃窦黏膜重度炎症患者中最高。
