Maciorkowska E, Kaczmarski M, Stasiak-Barmuta A, Kondej-Muszyńska K, Kemona A, Roszko I, Cieśla J, Zielińska A, Gocał M
III Department of Children's Diseases, Medical University of Białystok, 15-274 Białystok, J. Waszyngtona 17 (PL).
Rocz Akad Med Bialymst. 2003;48:95-9.
Helicobacter pylori infection in children is associated with a chronic inflammatory process of gastric and duodenal mucosa, which may have a various clinical course ranging from asymptomatic and chronic inflammatory condition to gastric ulceration. The immune system may contribute especially to chronic gastric mucosa inflammation. The aim of our study was to assess the levels of peripheral blood T (CD3+, CD4+, CD8+) and B lymphocyte subpopulation (CD19+) in children with Helicobacter pylori infection and to evaluate their relation to degree of antrum mucosa inflammation.
The study was performed in 32 children aged 7-18 years, hospitalized due to dyspeptic symptoms. The endoscopic examination of upper gastrointestinal tract was performed and gastric and duodenal mucosa was estimated in all patients. The endoscopic and histological evaluation of gastric mucosa was performed according to the Sydney System [4]. The urease test (CLO-test-H. pylori) was made to estimate the severity of the infection.
Moderate antrum mucosa inflammation was found in 41.2% of the examined. The highest percentage of children (58.8%) presented marked inflammation. No mild inflammation was found in children examined.
No correlation was found between lymphocyte levels and the degree of the inflammatory changes in antrum mucosa. The evaluation of peripheral blood lymphocytes performed in children with Helicobacter pylori infection suggests that T lymphocytes may play a predominant role in this infection.
儿童幽门螺杆菌感染与胃和十二指肠黏膜的慢性炎症过程相关，其临床病程多样，从无症状和慢性炎症状态到胃溃疡。免疫系统可能尤其促成慢性胃黏膜炎症。我们研究的目的是评估幽门螺杆菌感染儿童外周血T（CD3 +、CD4 +、CD8 +）和B淋巴细胞亚群（CD19 +）的水平，并评估它们与胃窦黏膜炎症程度的关系。
本研究对32名7 - 18岁因消化不良症状住院的儿童进行。对所有患者进行上消化道内镜检查，并评估胃和十二指肠黏膜。根据悉尼系统[4]对胃黏膜进行内镜和组织学评估。进行尿素酶试验（CLO试验 - 幽门螺杆菌）以评估感染的严重程度。
41.2%的受检者发现有中度胃窦黏膜炎症。最高比例的儿童（58.8%）呈现明显炎症。在受检儿童中未发现轻度炎症。
未发现淋巴细胞水平与胃窦黏膜炎症变化程度之间存在相关性。对幽门螺杆菌感染儿童进行的外周血淋巴细胞评估表明，T淋巴细胞可能在这种感染中起主要作用。
