Shibata Chikashi, Jin Xue-Lin, Funayama Yuji, Fukushima Kouhei, Takahashi Ken-Ichi, Hashimoto Akihiko, Nagao Munenori, Haneda Sho, Watanabe Kazuhiro, Matsuno Seiki, Sasaki Iwao, Naito Hiroo
Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.
Tohoku J Exp Med. 2004 Jan;202(1):57-61. doi: 10.1620/tjem.202.57.
We report a patient with synchronous multiple liver metastases from rectal cancer associated with ulcerative colitis. Because the liver tumors were unresectable, we performed total proctocolectomy and hepatic intra-arterial cisplatin infusion with systemic oral administration of fluorouracil. A complete response was obtained. The patient is alive without sign of recurrence 5 years postoperatively. Hepatic intra-arterial administration of cisplatin should be considered in the treatment of unresectable liver metastases from colorectal cancer.
我们报告了一例患有与溃疡性结肠炎相关的直肠癌同步多发肝转移的患者。由于肝肿瘤无法切除，我们进行了全直肠结肠切除术，并经肝动脉灌注顺铂，同时口服氟尿嘧啶进行全身给药。获得了完全缓解。患者术后5年仍存活，无复发迹象。在治疗结直肠癌不可切除的肝转移时，应考虑经肝动脉给予顺铂。
