Gunasekera Sarath P, Isbrucker Richard A, Longley Ross E, Wright Amy E, Pomponi Shirley A, Reed John K
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U.S. 1 North, Fort Pierce, FL 34946, USA.
J Nat Prod. 2004 Jan;67(1):110-1. doi: 10.1021/np030294c.
Plakolide A (1), a new alpha-exomethylene-gamma-lactone isolated from the marine sponge Plakortis sp., was found to inhibit inducible nitric oxide synthase (iNOS) activity. The isolation, structure elucidation, and biological activity of plakolide A is described.
普拉科利德A（1）是从海洋海绵Plakortis sp.中分离出的一种新型α-亚甲基-γ-内酯，被发现可抑制诱导型一氧化氮合酶（iNOS）的活性。本文描述了普拉科利德A的分离、结构解析及生物活性。
