Group Bioactivities of Natural Compounds and Derivatives (BIONA), Institut Pasteur of New Caledonia, Member of the Pasteur Network, Noumea 98845, New Caledonia.
Ifremer, Institut de Recherche pour le Développement (IRD), Centre Nationale de la Recherche Scientifique (CNRS), Université de la Réunion, Université de la Nouvelle-Calédonie, UMR 9220 ENTROPIE, 101 Promenade Roger Laroque, Noumea 98897, New Caledonia.
Mar Drugs. 2024 Sep 3;22(9):405. doi: 10.3390/md22090405.
The marine environment represents a formidable source of biodiversity, is still largely unexplored, and has high pharmacological potential. Indeed, several bioactive marine natural products (MNPs), including immunomodulators, have been identified in the past decades. Here, we review how this reservoir of bioactive molecules could be mobilized to develop novel anti-inflammatory compounds specially produced by or derived from marine microorganisms. After a detailed description of the MNPs exerting immunomodulatory potential and their biological target, we will briefly discuss the challenges associated with discovering anti-inflammatory compounds from marine microorganisms.
海洋环境代表了丰富的生物多样性来源，尽管目前仍有大量领域尚未被探索，但它具有巨大的药理学潜力。事实上，过去几十年来，人们已经在海洋中发现了几种具有生物活性的海洋天然产物（MNPs），包括免疫调节剂。在这里，我们将回顾如何利用这一生物活性分子库来开发新型抗炎化合物，这些化合物是专门由海洋微生物产生或衍生而来的。在详细描述具有免疫调节潜力的 MNPs 及其生物靶标之后，我们将简要讨论从海洋微生物中发现抗炎化合物所面临的挑战。
