Chowdhury A R, Gautam A K, Patel K G, Trivedi H S
National Institute of Occupational Health, (Indian Council of Medical Research), Meghani Nagar, Ahmedabad.
Indian J Physiol Pharmacol. 1992 Jul;36(3):162-8.
Three groups of rats (n = 10) were subjected to intraperitoneal treatment of formaldehyde daily at doses of 5, 10 and 15 mg/kg body weight over a period of 30 days. Gradual diminution in body and testicular weight was observed in all treated groups. Leyding cell impairement was conspicuous in those given doses of 10 and 15 mg/kg. Inhibition of 3 beta-delta 5-hydroxy steroid dehydrogenase and accumulation of sudanophillic materials in testicular tissue of formaldehyde treated rats was recorded histochemically. Significant decline of serum testosterone was also observed in the same groups. Structural and functional impairement of Leydig cells after formaldehyde treatment caused steroidogenic inhibition.
将三组大鼠（每组n = 10）每天腹腔注射甲醛，剂量分别为5、10和15毫克/千克体重，持续30天。在所有治疗组中均观察到体重和睾丸重量逐渐减轻。在给予10毫克/千克和15毫克/千克剂量的组中，睾丸间质细胞损伤明显。组织化学记录显示，甲醛处理的大鼠睾丸组织中3β-δ5-羟基类固醇脱氢酶受到抑制，嗜苏丹物质积累。在同一组中还观察到血清睾酮显著下降。甲醛处理后睾丸间质细胞的结构和功能损伤导致类固醇生成抑制。
