Bohus Martin, Schmahl Christian, Lieb Klaus
Central Institute of Mental Health Mannheim, University of Heidelberg, J 5, 68159 Mannheim, Germany.
Curr Psychiatry Rep. 2004 Feb;6(1):43-50. doi: 10.1007/s11920-004-0038-4.
Within the past several years, research on the clinical phenomena and neurobiology of borderline personality disorder has increased substantially. Borderline personality disorder is currently best thought of in terms of dimensions rather than as a categorical disorder. This article reviews the most recent findings on two of the core dimensions--affective dysregulation and impulsivity. Most of the neuropsychologic, physiologic, endocrinologic, and neuroimaging data support the theory that a dual brain pathology, affecting prefrontal and limbic circuits, may underlie this hyperarousal-dyscontrol syndrome.
在过去几年中，关于边缘型人格障碍的临床现象和神经生物学的研究大幅增加。目前，边缘型人格障碍最好从维度角度而非分类障碍的角度来理解。本文回顾了关于两个核心维度——情感失调和冲动性的最新研究结果。大多数神经心理学、生理学、内分泌学和神经影像学数据支持这样一种理论，即影响前额叶和边缘系统回路的双重脑病理可能是这种过度唤醒-失控综合征的基础。
