重组：霍利迪连接体的拆分与交叉形成。
Recombination: Holliday junction resolution and crossover formation.
作者信息
Heyer Wolf Dietrich
机构信息
Division of Biological Sciences, Section of Microbiology and Center for Genetics and Development, University of California, Davis, California 95616-8665, USA.
出版信息
Curr Biol. 2004 Jan 20;14(2):R56-8. doi: 10.1016/j.cub.2003.12.043.
PMID:14738748
Abstract
The heterodimeric nuclease Mus81-Eme1 has been proposed to be a Holliday junction resolvase and has now been found to be responsible for nearly all meiotic crossovers in fission yeast. The intriguing substrate preference of this enzyme for nicked Holliday junctions opens the possibility that crossover formation may not always involve double Holliday junctions.
摘要
异源二聚体核酸酶Mus81-Eme1被认为是一种Holliday连接体解离酶，现在发现它几乎负责裂殖酵母中所有的减数分裂交叉互换。这种酶对带切口的Holliday连接体具有有趣的底物偏好性，这使得交叉互换形成可能并不总是涉及双Holliday连接体成为一种可能。
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