• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

重组：霍利迪连接体的拆分与交叉形成。

Recombination: Holliday junction resolution and crossover formation.

作者信息

Heyer Wolf Dietrich

机构信息

Division of Biological Sciences, Section of Microbiology and Center for Genetics and Development, University of California, Davis, California 95616-8665, USA.

出版信息

Curr Biol. 2004 Jan 20;14(2):R56-8. doi: 10.1016/j.cub.2003.12.043.

DOI:10.1016/j.cub.2003.12.043
PMID:14738748
Abstract

The heterodimeric nuclease Mus81-Eme1 has been proposed to be a Holliday junction resolvase and has now been found to be responsible for nearly all meiotic crossovers in fission yeast. The intriguing substrate preference of this enzyme for nicked Holliday junctions opens the possibility that crossover formation may not always involve double Holliday junctions.

摘要

异源二聚体核酸酶Mus81-Eme1被认为是一种Holliday连接体解离酶，现在发现它几乎负责裂殖酵母中所有的减数分裂交叉互换。这种酶对带切口的Holliday连接体具有有趣的底物偏好性，这使得交叉互换形成可能并不总是涉及双Holliday连接体成为一种可能。

相似文献

1
Recombination: Holliday junction resolution and crossover formation.重组：霍利迪连接体的拆分与交叉形成。
Curr Biol. 2004 Jan 20;14(2):R56-8. doi: 10.1016/j.cub.2003.12.043.
2
Generating crossovers by resolution of nicked Holliday junctions: a role for Mus81-Eme1 in meiosis.通过有切口的霍利迪连接体的拆分产生交叉：Mus81-Eme1在减数分裂中的作用
Mol Cell. 2003 Sep;12(3):761-74. doi: 10.1016/s1097-2765(03)00343-5.
3
Mus81-Eme1 are essential components of a Holliday junction resolvase.Mus81-Eme1是霍利迪连接体解离酶的重要组成部分。
Cell. 2001 Nov 16;107(4):537-48. doi: 10.1016/s0092-8674(01)00536-0.
4
Fission yeast Mus81.Eme1 Holliday junction resolvase is required for meiotic crossing over but not for gene conversion.裂殖酵母Mus81.Eme1霍利迪连接体解离酶是减数分裂交叉所必需的，但不是基因转换所必需的。
Genetics. 2003 Dec;165(4):2289-93. doi: 10.1093/genetics/165.4.2289.
5
The human Holliday junction resolvase GEN1 rescues the meiotic phenotype of a Schizosaccharomyces pombe mus81 mutant.人类 Holliday junction 解旋酶 GEN1 挽救了酿酒酵母 pombe mus81 突变体的减数分裂表型。
Nucleic Acids Res. 2010 Apr;38(6):1866-73. doi: 10.1093/nar/gkp1179. Epub 2009 Dec 29.
6
The Mus81/Mms4 endonuclease acts independently of double-Holliday junction resolution to promote a distinct subset of crossovers during meiosis in budding yeast.Mus81/Mms4核酸内切酶在芽殖酵母减数分裂过程中独立于双Holliday连接体的解离发挥作用，以促进特定的交叉子集。
Genetics. 2003 May;164(1):81-94. doi: 10.1093/genetics/164.1.81.
7
Mus81 cleavage of Holliday junctions: a failsafe for processing meiotic recombination intermediates?Holliday连接体的Mus81切割：处理减数分裂重组中间体的一种安全机制？
EMBO J. 2007 Apr 4;26(7):1891-901. doi: 10.1038/sj.emboj.7601645. Epub 2007 Mar 15.
8
Regulated Crossing-Over Requires Inactivation of Yen1/GEN1 Resolvase during Meiotic Prophase I.调控同源重组需要 Yen1/GEN1 核酸内切酶在减数分裂前期 I 失活。
Dev Cell. 2018 Jun 18;45(6):785-800.e6. doi: 10.1016/j.devcel.2018.05.020.
9
The Cdc14 Phosphatase Controls Resolution of Recombination Intermediates and Crossover Formation during Meiosis.Cdc14 磷酸酶在减数分裂过程中控制重组中间体的解决和交叉形成。
Int J Mol Sci. 2021 Sep 10;22(18):9811. doi: 10.3390/ijms22189811.
10
The Mus81 solution to resolution: generating meiotic crossovers without Holliday junctions.Mus81解决重组问题的方式：在没有霍利迪连接体的情况下产生减数分裂交叉。
Genes Dev. 2004 Jan 15;18(2):117-25. doi: 10.1101/gad.1165904.

引用本文的文献

1
Analysis of rad-51 separation of function allele suggests divergence of the synthesis-dependent strand annealing and double Holliday junction pathways prior to RAD-51 filament disassembly.对功能等位基因的rad-51分离分析表明，在RAD-51细丝解体之前，合成依赖链退火和双Holliday连接途径就已出现分歧。
Genetics. 2025 Jun 4;230(2). doi: 10.1093/genetics/iyaf063.
2
Pentaploidization Enriches the Genetic Diversity of Wheat by Enhancing the Recombination of AB Genomes.五倍体化通过增强AB基因组的重组来丰富小麦的遗传多样性。
Front Plant Sci. 2022 Jun 29;13:883868. doi: 10.3389/fpls.2022.883868. eCollection 2022.
3
Meiotic Genes and DNA Double Strand Break Repair in Cancer.
减数分裂基因与癌症中的DNA双链断裂修复
Front Genet. 2022 Feb 18;13:831620. doi: 10.3389/fgene.2022.831620. eCollection 2022.
4
DNA topoisomerases: Advances in understanding of cellular roles and multi-protein complexes via structure-function analysis.DNA 拓扑异构酶：通过结构-功能分析深入了解细胞作用和多蛋白复合物。
Bioessays. 2021 Apr;43(4):e2000286. doi: 10.1002/bies.202000286. Epub 2021 Jan 22.
5
The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans.保守的 LEM-3/Ankle1 核酸酶参与了秀丽隐杆线虫减数分裂重组修复和染色体分离的组合调控。
PLoS Genet. 2018 Jun 7;14(6):e1007453. doi: 10.1371/journal.pgen.1007453. eCollection 2018 Jun.
6
Age-Dependent Alterations in Meiotic Recombination Cause Chromosome Segregation Errors in Spermatocytes.减数分裂重组中与年龄相关的变化导致精母细胞染色体分离错误。
Cell. 2017 Oct 19;171(3):601-614.e13. doi: 10.1016/j.cell.2017.08.042. Epub 2017 Sep 21.
7
Mutator Phenotype and DNA Double-Strand Break Repair in BLM Helicase-Deficient Human Cells.BLM解旋酶缺陷型人类细胞中的突变体表型与DNA双链断裂修复
Mol Cell Biol. 2016 Nov 14;36(23):2877-2889. doi: 10.1128/MCB.00443-16. Print 2016 Dec 1.
8
Hold your horSSEs: controlling structure-selective endonucleases MUS81 and Yen1/GEN1.别急：控制结构选择性核酸内切酶MUS81和Yen1/GEN1。
Front Genet. 2015 Jul 30;6:253. doi: 10.3389/fgene.2015.00253. eCollection 2015.
9
The ERCC1 and ERCC4 (XPF) genes and gene products.ERCC1和ERCC4（XPF）基因及基因产物。
Gene. 2015 Sep 15;569(2):153-61. doi: 10.1016/j.gene.2015.06.026. Epub 2015 Jun 12.
10
Understanding the DNA damage response in order to achieve desired gene editing outcomes in mosquitoes.了解DNA损伤反应以在蚊子中实现理想的基因编辑结果。
Chromosome Res. 2015 Feb;23(1):31-42. doi: 10.1007/s10577-014-9450-8.